LeHavreV1, Main, Exploration, bibRecord, 001226

A model of antibiotic-resistant bacterial epidemics in hospitals

Identifieur interne : 001226 ( Main/Exploration ); précédent : 001225; suivant : 001227

A model of antibiotic-resistant bacterial epidemics in hospitals

Auteurs : Glenn F. Webb [États-Unis] ; Erika M. C. D'Agata [États-Unis] ; Pierre Magal [France] ; Shigui Ruan [États-Unis]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2005.

RBID : PMC:1201589

Abstract

The emergence of drug-resistant strains of bacteria is an increasing threat to society, especially in hospital settings. Many antibiotics that were formerly effective in combating bacterial infections in hospital patients are no longer effective because of the evolution of resistant strains, which compromises medical care worldwide. In this article, we formulate a two-level population model to quantify key elements in nosocomial (hospital-acquired) infections. At the bacteria level, patients infected with these strains generate both nonresistant and resistant bacteria. At the patient level, susceptible patients are infected by infected patients at rates proportional to the total bacteria load of each strain present in the hospital. The objectives of this paper are to analyze the dynamic elements of nonresistant and resistant bacteria strains in epidemic populations in hospital environments and to provide understanding of measures to avoid the endemicity of resistant antibiotic strains.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201589

DOI: 10.1073/pnas.0504053102
PubMed: 16141326
PubMed Central: 1201589

Affiliations:

Le document en format XML

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A model of antibiotic-resistant bacterial epidemics in hospitals

A model of antibiotic-resistant bacterial epidemics in hospitals

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